The p97-Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8

The p97-Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8

<p style="text-align:justify;"> The E3 ubiquitin ligase RNF8 (RING finger protein 8) is a pivotal enzyme for DNA repair. However, RNF8 hyper‐accumulation is tumour‐promoting and positively correlates with genome instability, cancer cell invasion, metastasis and poor patient prognosi...

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Bibliographic Details
Main Authors: Singh, A, Oehler, J, Torrecilla, I, Kilgas, S, Li, S, Vaz, B, Guérillon, C, Fielden, J, Hernandez-Carralero, E, Cabrera, E, Tullis, I, Meerang, M, Barber, P, Freire, R, Parsons, J, Vojnovic, B, Kiltie, A, Mailand, N, Ramadan, K
Format: Journal article
Language:English
Published: EMBO Press 2019

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