Diastereoselectivity in the alkylations of bicyclic piperidinones
The synthesis of substituted [4.3.0] bicyclic lactams derived from 6- oxo-2-hydroxymethylpiperidine is described. The enolate derived flora these systems can be alkylated with a range of reactive electrophiles; the diastereoselectivity which can be achieved depends on the substitution pattern of the...
| Main Authors: | , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
1998
|