Synthesis and homologation of an azetidin-2-yl boronic ester with α-lithioalkyl triisopropylbenzoates
An α-boryl azetidine, obtained by α-lithiation-borylation of N-Botc azetidine, undergoes reaction with α-triisopropylbenzoyloxy organolithiums to give homologated boronic esters that can be further oxidized, homologated, arylated, and deprotected to give a range of α-substituted azetidines. Scalemic...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
American Chemical Society
2019
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