Evaluating beta-amino acids as enantioselective organocatalysts of the Hajos-Parrish-Eder-Sauer-Wiechert reaction.
A systematic study of the effect of substitution within the beta-amino acid framework indicates that both beta(2)- and beta(3)-amino acids catalyse the Hajos-Parrish-Eder-Sauer-Wiechert reaction with poor to reasonable levels of enantioselectivity. These results led to the evaluation of the conforma...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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2007
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| _version_ | 1826261468461400064 |
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| author | Davies, S Russell, A Sheppard, R Smith, A Thomson, J |
| author_facet | Davies, S Russell, A Sheppard, R Smith, A Thomson, J |
| author_sort | Davies, S |
| collection | OXFORD |
| description | A systematic study of the effect of substitution within the beta-amino acid framework indicates that both beta(2)- and beta(3)-amino acids catalyse the Hajos-Parrish-Eder-Sauer-Wiechert reaction with poor to reasonable levels of enantioselectivity. These results led to the evaluation of the conformationally constrained beta-amino acid (1R,2S)-cispentacin, which catalyses the Hajos-Parrish-Eder-Sauer-Wiechert reaction with comparable or higher levels of enantioselectivity to L-proline. |
| first_indexed | 2024-03-06T19:21:56Z |
| format | Journal article |
| id | oxford-uuid:1a64226b-bab0-4caa-9e3e-3994ec60ae9d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:21:56Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:1a64226b-bab0-4caa-9e3e-3994ec60ae9d2022-03-26T10:54:35ZEvaluating beta-amino acids as enantioselective organocatalysts of the Hajos-Parrish-Eder-Sauer-Wiechert reaction.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:1a64226b-bab0-4caa-9e3e-3994ec60ae9dEnglishSymplectic Elements at Oxford2007Davies, SRussell, ASheppard, RSmith, AThomson, JA systematic study of the effect of substitution within the beta-amino acid framework indicates that both beta(2)- and beta(3)-amino acids catalyse the Hajos-Parrish-Eder-Sauer-Wiechert reaction with poor to reasonable levels of enantioselectivity. These results led to the evaluation of the conformationally constrained beta-amino acid (1R,2S)-cispentacin, which catalyses the Hajos-Parrish-Eder-Sauer-Wiechert reaction with comparable or higher levels of enantioselectivity to L-proline. |
| spellingShingle | Davies, S Russell, A Sheppard, R Smith, A Thomson, J Evaluating beta-amino acids as enantioselective organocatalysts of the Hajos-Parrish-Eder-Sauer-Wiechert reaction. |
| title | Evaluating beta-amino acids as enantioselective organocatalysts of the Hajos-Parrish-Eder-Sauer-Wiechert reaction. |
| title_full | Evaluating beta-amino acids as enantioselective organocatalysts of the Hajos-Parrish-Eder-Sauer-Wiechert reaction. |
| title_fullStr | Evaluating beta-amino acids as enantioselective organocatalysts of the Hajos-Parrish-Eder-Sauer-Wiechert reaction. |
| title_full_unstemmed | Evaluating beta-amino acids as enantioselective organocatalysts of the Hajos-Parrish-Eder-Sauer-Wiechert reaction. |
| title_short | Evaluating beta-amino acids as enantioselective organocatalysts of the Hajos-Parrish-Eder-Sauer-Wiechert reaction. |
| title_sort | evaluating beta amino acids as enantioselective organocatalysts of the hajos parrish eder sauer wiechert reaction |
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