Mutation at Ser392 specifically sensitizes mutant p53H175 to mdm2-mediated degradation.
Mdm2 is one of the main E3 ubiquitin ligases, which targets both wild type and mutant p53 for degradation. The ability of post-translational modifications, such as phosphorylation, to modulate the function and stability of wild type p53 has been extensively studied. However, their ability to modulat...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2010
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