Tertiary element interaction in HIV-1 TAR

HIV-1 replication requires binding to occur between Trans-activation Response Element (TAR) RNA and the TAT protein. This TAR-TAT binding depends on the conformation of TAR, and therapeutic development has attempted to exploit this dynamic behavior. Here we simulate TAR dynamics in the context of mu...

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Bibliographic Details
Main Authors: Krawczyk, K, Sim, A, Knapp, B, Deane, C, Minary, P
Format: Journal article
Language:English
Published: American Chemical Society 2016