Tertiary element interaction in HIV-1 TAR
HIV-1 replication requires binding to occur between Trans-activation Response Element (TAR) RNA and the TAT protein. This TAR-TAT binding depends on the conformation of TAR, and therapeutic development has attempted to exploit this dynamic behavior. Here we simulate TAR dynamics in the context of mu...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
American Chemical Society
2016
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| _version_ | 1797056361894248448 |
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| author | Krawczyk, K Sim, A Knapp, B Deane, C Minary, P |
| author_facet | Krawczyk, K Sim, A Knapp, B Deane, C Minary, P |
| author_sort | Krawczyk, K |
| collection | OXFORD |
| description | HIV-1 replication requires binding to occur between Trans-activation Response Element (TAR) RNA and the TAT protein. This TAR-TAT binding depends on the conformation of TAR, and therapeutic development has attempted to exploit this dynamic behavior. Here we simulate TAR dynamics in the context of mutations inhibiting TAR binding. We find that two tertiary elements, the apical loop and the bulge, can interact directly, and this interaction may be linked to the affinity of TAR for TAT. |
| first_indexed | 2024-03-06T19:22:20Z |
| format | Journal article |
| id | oxford-uuid:1a87c109-bde2-4bb2-9702-acfca95fa641 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:22:20Z |
| publishDate | 2016 |
| publisher | American Chemical Society |
| record_format | dspace |
| spelling | oxford-uuid:1a87c109-bde2-4bb2-9702-acfca95fa6412022-03-26T10:55:20ZTertiary element interaction in HIV-1 TARJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:1a87c109-bde2-4bb2-9702-acfca95fa641EnglishSymplectic Elements at OxfordAmerican Chemical Society2016Krawczyk, KSim, AKnapp, BDeane, CMinary, PHIV-1 replication requires binding to occur between Trans-activation Response Element (TAR) RNA and the TAT protein. This TAR-TAT binding depends on the conformation of TAR, and therapeutic development has attempted to exploit this dynamic behavior. Here we simulate TAR dynamics in the context of mutations inhibiting TAR binding. We find that two tertiary elements, the apical loop and the bulge, can interact directly, and this interaction may be linked to the affinity of TAR for TAT. |
| spellingShingle | Krawczyk, K Sim, A Knapp, B Deane, C Minary, P Tertiary element interaction in HIV-1 TAR |
| title | Tertiary element interaction in HIV-1 TAR |
| title_full | Tertiary element interaction in HIV-1 TAR |
| title_fullStr | Tertiary element interaction in HIV-1 TAR |
| title_full_unstemmed | Tertiary element interaction in HIV-1 TAR |
| title_short | Tertiary element interaction in HIV-1 TAR |
| title_sort | tertiary element interaction in hiv 1 tar |
| work_keys_str_mv | AT krawczykk tertiaryelementinteractioninhiv1tar AT sima tertiaryelementinteractioninhiv1tar AT knappb tertiaryelementinteractioninhiv1tar AT deanec tertiaryelementinteractioninhiv1tar AT minaryp tertiaryelementinteractioninhiv1tar |