AKR1D1 is a novel regulator of metabolic phenotype in human hepatocytes and is dysregulated in non-alcoholic fatty liver disease.

AKR1D1 is a novel regulator of metabolic phenotype in human hepatocytes and is dysregulated in non-alcoholic fatty liver disease.

<p><strong>OBJECTIVE:</strong> Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome. Steroid hormones and bile acids are potent regulators of hepatic carbohydrate and lipid metabolism. Steroid 5β-reductase (AKR1D1) is highly expressed in huma...

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Bibliographic Details
Main Authors: Nikolaou, N, Gathercole, L, Marchand, L, Althari, S, Dempster, N, Green, C, Van De Bunt, M, McNeil, C, Arvaniti, A, Hughes, B, Sgromo, B, Gillies, R, Marschall, H, Penning, T, Ryan, J, Arlt, W, Hodson, L, Tomlinson, J
Format: Journal article
Language:English
Published: Elsevier 2019

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