Enhancers predominantly regulate gene expression during differentiation via transcription initiation

Gene transcription occurs via a cycle of linked events, including initiation, promoter-proximal pausing, and elongation of RNA polymerase II (Pol II). A key question is how transcriptional enhancers influence these events to control gene expression. Here, we present an approach that evaluates the le...

Full description

Bibliographic Details
Main Authors: Larke, MSC, Schwessinger, R, Nojima, T, Telenius, J, Beagrie, RA, Downes, DJ, Oudelaar, AM, Truch, J, Graham, B, Bender, MA, Proudfoot, NJ, Higgs, DR, Hughes, JR
Format: Journal article
Language:English
Published: Cell Press 2021