Azacitidine fails to eradicate leukemic stem/progenitor cell populations in patients with acute myeloid leukemia and myelodysplasia

Azacitidine fails to eradicate leukemic stem/progenitor cell populations in patients with acute myeloid leukemia and myelodysplasia

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Epigenetic therapies demonstrate significant clinical activity in acute myeloid leukemia (AML) and myelodysplasia (MDS) and constitute an important new class of therapeutic agents. However hematological responses are not durable and disease relapse appears inevitable. Experimentally, leukemic stem/p...

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Bibliographic Details
Main Authors: Craddock, C, Freeman, S, Siddique, S, Raghavan, M, McSkeane, T, Arrazi, J, Brookes, C, Quek, L, Goardon, N, Aztberger, A, Vyas, P, Schuh, A, Grimwade, D, Ivey, A, Virgo, P, Hills, R, Knapper, S, Burnett, A, Davies, B, Price, A, Wall, K, Griffiths, M, Cavenagh, J, Majeti, R, Weissman, I
Format: Journal article
Published: 2013

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