A GMP protocol for the manufacture of Tregs for clinical application

Infusion of regulatory T cells is a promising therapeutic strategy in organ transplantation to modulate the immune system, prevent rejection, minimize the need for pharmaceutical immunosuppression, and improve long-term transplant outcomes. Here we describe a GMP-compliant method we have used for th...

Полное описание

Библиографические подробности
Главные авторы: O'Neil, A, Brook, M, Abdul-Wahab, S, Hester, J, Lombardi, G, Issa, F
Формат: Book section
Язык:English
Опубликовано: Humana Press 2022
Описание
Итог:Infusion of regulatory T cells is a promising therapeutic strategy in organ transplantation to modulate the immune system, prevent rejection, minimize the need for pharmaceutical immunosuppression, and improve long-term transplant outcomes. Here we describe a GMP-compliant method we have used for the manufacture of ex vivo expanded autologous regulatory T cells for use in clinical trials.