Change in specificity of glycosidase inhibition by N-alkylation of amino sugars.
The synthetic amino sugar 1,4-dideoxy-1,4-imino-L-allitol (DIA) is a moderately good inhibitor of human liver alpha-D-mannosidases and a weak inhibitor of alpha-L-fucosidase, N-acetyl-beta-D-hexosaminidase and beta-D-mannosidase. Methylation of the ring nitrogen of DIA markedly decreases the inhibit...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1989
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