Temporal changes in SARS-CoV-2 clearance kinetics and the optimal design of antiviral pharmacodynamic studies: an individual patient data meta-analysis of a randomised, controlled, adaptive platform study (PLATCOV)

Temporal changes in SARS-CoV-2 clearance kinetics and the optimal design of antiviral pharmacodynamic studies: an individual patient data meta-analysis of a randomised, controlled, adaptive platform study (PLATCOV)

<p><strong>Background</p></strong> Effective antiviral drugs prevent hospitalisation and death from COVID-19. Antiviral efficacy can be efficiently assessed in vivo by measuring rates of SARS-CoV-2 clearance estimated from serial viral genome densities quantitated in nasophar...

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Dades bibliogràfiques
Autors principals: Wongnak, P, Schilling, WHK, Jittamala, P, Boyd, S, Luvira, V, Siripoon, T, Ngamprasertchai, T, Batty, EM, Singh, S, Kouhathong, J, Pagornrat, W, Khanthagan, P, Hanboonkunupakarn, B, Poovorawan, K, Mayxay, M, Chotivanich, K, Imwong, M, Pukrittayakamee, S, Ashley, EA, Dondorp, AM, Day, NPJ, Teixeira, MM, Piyaphanee, W, Phumratanaprapin, W, White, NJ, Watson, JA
Altres autors: PLATCOV Collaborative Group
Format: Journal article
Idioma:English
Publicat: Elsevier 2024

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