Cotrimoxazole reduces systemic inflammation in HIV infection by altering the gut microbiome and immune activation

Long-term cotrimoxazole prophylaxis reduces mortality and morbidity in HIV infection, but the mechanisms underlying these clinical benefits are unclear. Here, we investigate the impact of cotrimoxazole on systemic inflammation, an independent driver of HIV mortality. In HIV-positive Ugandan and Zimb...

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Bibliografiska uppgifter
Huvudupphovsmän:	Bourke, CD, Gough, EK, Pimundu, G, Shonhai, A, Berejena, C, Terry, L, Baumard, L, Choudhry, N, Karmali, Y, Bwarkura-Dangarembizi, M, Musiime, V, Lutaakome, J, Kekitiinwa, A, Mutasa, K, Szubert, AJ, Spyer, MJ, Deayton, JR, Glass, M, Geum, HM, Pardieu, C, Gibb, DM, Klein, N, Edens, TJ, Walker, AS, Manges, AR, Prendergast, AJ
Materialtyp:	Journal article
Publicerad:	American Association for the Advancement of Science 2019

Cotrimoxazole reduces systemic inflammation in HIV infection by altering the gut microbiome and immune activation

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