Kinetics of abacavir-induced remodelling of the major histocompatibility complex class I peptide repertoire

Abacavir hypersensitivity syndrome can occur in individuals expressing the HLA-B*57:01 major histocompatibility complex class I allotype when utilising the drug abacavir as a part of their anti-retroviral regimen. The drug is known to bind within the HLA-B*57:01 antigen binding cleft, leading to the...

Полное описание

Библиографические подробности
Главные авторы: Illing, PT, van Hateren, A, Darley, R, Croft, NP, Mifsud, NA, King, S, Kostenko, L, Bharadwaj, M, McCluskey, J, Elliott, T, Purcell, AW
Формат: Journal article
Язык:English
Опубликовано: Frontiers Media 2021