Effect of supplementation with flaxseed oil and different doses of fish oil for two weeks on plasma phosphatidylcholine fatty acids in young women.
<h4>Background/Objective</h4> <p>Although assumed, it remains unclear that fatty acid (FA) biomarkers of n-3 long-chain PUFA reflect wide ranges of intake. However, to be utilised as biomarkers, to predict dietary intake, dose-response curves that cover a spectrum of intakes are r...
| Main Authors: | , , , |
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| Format: | Journal article |
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Nature Publishing Group
2018
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| _version_ | 1797056848090628096 |
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| author | Hodson, L Crowe, F McLachlan, K Skeaff, C |
| author_facet | Hodson, L Crowe, F McLachlan, K Skeaff, C |
| author_sort | Hodson, L |
| collection | OXFORD |
| description | <h4>Background/Objective</h4> <p>Although assumed, it remains unclear that fatty acid (FA) biomarkers of n-3 long-chain PUFA reflect wide ranges of intake. However, to be utilised as biomarkers, to predict dietary intake, dose-response curves that cover a spectrum of intakes are required. The aim of the study was to investigate whether the FA composition of plasma phosphatidylcholine (PC) is a sensitive biomarker of n-3 FAs from fish oil, across a range of supplementation doses, and alpha-linolenic acid (ALA) supplementation, in young, healthy women.</p> <h4>Subjects/Methods</h4> <p>A total of 303 young women were randomized to intakes ranging between 0.33 and 4.50 g EPA+DHA/day from fish oil (not all doses used in each year) or flaxseed oil (5.90–6.60 g/day) daily for 14 days in a series of trials, over five years. Fasting blood was collected at baseline (Day 0) and day 14 and plasma PC FA composition, total and HDL-cholesterol and triacylglycerol concentrations measured.</p> <h4>Results</h4> <p>Fourteen days supplementation with fish oil significantly (P<0.01) increased, in a dose-dependent fashion, plasma PC EPA, DPA and DHA at all doses except 1 and 3 mL/day. For the combined group of women who consumed any fish oil there was a 16% (P<0.01) decrease in plasma triacylglycerol concentrations after 14 days supplementation. Flaxseed oil supplementation for 14 day resulted in significant (P<0.01) increases in ALA, EPA and DPA, whilst DHA remained unchanged.</p> <h4>Conclusion</h4> <p>Our data demonstrate plasma PC is a sensitive biomarker of n-3 FA intake and reflects changes within 14 days across a range of intakes.</p> |
| first_indexed | 2024-03-06T19:28:15Z |
| format | Journal article |
| id | oxford-uuid:1c89766f-604d-40ab-8682-ee0801624bc3 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T19:28:15Z |
| publishDate | 2018 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | oxford-uuid:1c89766f-604d-40ab-8682-ee0801624bc32022-03-26T11:06:10ZEffect of supplementation with flaxseed oil and different doses of fish oil for two weeks on plasma phosphatidylcholine fatty acids in young women.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:1c89766f-604d-40ab-8682-ee0801624bc3Symplectic Elements at OxfordNature Publishing Group2018Hodson, LCrowe, FMcLachlan, KSkeaff, C <h4>Background/Objective</h4> <p>Although assumed, it remains unclear that fatty acid (FA) biomarkers of n-3 long-chain PUFA reflect wide ranges of intake. However, to be utilised as biomarkers, to predict dietary intake, dose-response curves that cover a spectrum of intakes are required. The aim of the study was to investigate whether the FA composition of plasma phosphatidylcholine (PC) is a sensitive biomarker of n-3 FAs from fish oil, across a range of supplementation doses, and alpha-linolenic acid (ALA) supplementation, in young, healthy women.</p> <h4>Subjects/Methods</h4> <p>A total of 303 young women were randomized to intakes ranging between 0.33 and 4.50 g EPA+DHA/day from fish oil (not all doses used in each year) or flaxseed oil (5.90–6.60 g/day) daily for 14 days in a series of trials, over five years. Fasting blood was collected at baseline (Day 0) and day 14 and plasma PC FA composition, total and HDL-cholesterol and triacylglycerol concentrations measured.</p> <h4>Results</h4> <p>Fourteen days supplementation with fish oil significantly (P<0.01) increased, in a dose-dependent fashion, plasma PC EPA, DPA and DHA at all doses except 1 and 3 mL/day. For the combined group of women who consumed any fish oil there was a 16% (P<0.01) decrease in plasma triacylglycerol concentrations after 14 days supplementation. Flaxseed oil supplementation for 14 day resulted in significant (P<0.01) increases in ALA, EPA and DPA, whilst DHA remained unchanged.</p> <h4>Conclusion</h4> <p>Our data demonstrate plasma PC is a sensitive biomarker of n-3 FA intake and reflects changes within 14 days across a range of intakes.</p> |
| spellingShingle | Hodson, L Crowe, F McLachlan, K Skeaff, C Effect of supplementation with flaxseed oil and different doses of fish oil for two weeks on plasma phosphatidylcholine fatty acids in young women. |
| title | Effect of supplementation with flaxseed oil and different doses of fish oil for two weeks on plasma phosphatidylcholine fatty acids in young women. |
| title_full | Effect of supplementation with flaxseed oil and different doses of fish oil for two weeks on plasma phosphatidylcholine fatty acids in young women. |
| title_fullStr | Effect of supplementation with flaxseed oil and different doses of fish oil for two weeks on plasma phosphatidylcholine fatty acids in young women. |
| title_full_unstemmed | Effect of supplementation with flaxseed oil and different doses of fish oil for two weeks on plasma phosphatidylcholine fatty acids in young women. |
| title_short | Effect of supplementation with flaxseed oil and different doses of fish oil for two weeks on plasma phosphatidylcholine fatty acids in young women. |
| title_sort | effect of supplementation with flaxseed oil and different doses of fish oil for two weeks on plasma phosphatidylcholine fatty acids in young women |
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