Tbx2 is overexpressed and plays an important role in maintaining proliferation and suppression of senescence in melanomas.
The INK4a and ARF genes found at the CDKN2A locus are key effectors of cellular senescence that is believed to act as a powerful anticancer mechanism. Accordingly, mutations in these genes are present in a wide variety of spontaneous human cancers and CDKN2A germ line mutations are found in familial...
| Main Authors: | , , , |
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| 格式: | Journal article |
| 語言: | English |
| 出版: |
2005
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