HIV control through a single nucleotide on the HLA-B locus.

HIV control through a single nucleotide on the HLA-B locus.

Genetic variation within the HLA-B locus has the strongest impact on HIV disease progression of any polymorphisms within the human genome. However, identifying the exact mechanism involved is complicated by several factors. HLA-Bw4 alleles provide ligands for NK cells and for CD8 T cells, and strong...

Full description

Bibliographic Details
Main Authors: Kløverpris, H, Harndahl, M, Leslie, A, Carlson, J, Ismail, N, van der Stok, M, Huang, K, Chen, F, Riddell, L, Steyn, D, Goedhals, D, van Vuuren, C, Frater, J, Walker, B, Carrington, M, Ndung'u, T, Buus, S, Goulder, P
Format: Journal article
Language:English
Published: 2012

Similar Items