Cryo-EM structures of apo-APC/C and APC/C CDH1:EMI1 complexes provide insights into APC/C regulation

APC/C is a multi-subunit complex that functions as a master regulator of cell division. It controls progression through the cell cycle by timely marking mitotic cyclins and other cell cycle regulatory proteins for degradation. The APC/C itself is regulated by the sequential action of its coactivator...

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التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Höfler, A, Yu, J, Yang, J, Zhang, Z, Chang, L, McLaughlin, SH, Grime, GW, Garman, EF, Boland, A, Barford, D
التنسيق: Journal article
اللغة:English
منشور في: Nature Research 2024