Bifunctional iminophosphorane catalyzed enantioselective ketimine phospha-Mannich reaction
The enantioselective phospha-Mannich reaction of diethyl phosphite to unactivated N-DPP-protected ketimines catalyzed by a bifunctional iminophosphorane (BIMP) superbase organocatalyst is described. The reaction is applicable to ketimines bearing electron-rich and electron-poor aryl substituents and...
| Main Authors: | , , |
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| Format: | Journal article |
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Thieme Publishing
2015
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| _version_ | 1826262024425832448 |
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| author | Robertson, G Farley, A Dixon, D |
| author_facet | Robertson, G Farley, A Dixon, D |
| author_sort | Robertson, G |
| collection | OXFORD |
| description | The enantioselective phospha-Mannich reaction of diethyl phosphite to unactivated N-DPP-protected ketimines catalyzed by a bifunctional iminophosphorane (BIMP) superbase organocatalyst is described. The reaction is applicable to ketimines bearing electron-rich and electron-poor aryl substituents and occurs with excellent yields and moderate enantioselectivities under mild reaction conditions. |
| first_indexed | 2024-03-06T19:29:49Z |
| format | Journal article |
| id | oxford-uuid:1d13c380-9a4d-4c1f-9255-703d3bbf3013 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T19:29:49Z |
| publishDate | 2015 |
| publisher | Thieme Publishing |
| record_format | dspace |
| spelling | oxford-uuid:1d13c380-9a4d-4c1f-9255-703d3bbf30132022-03-26T11:08:52ZBifunctional iminophosphorane catalyzed enantioselective ketimine phospha-Mannich reactionJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:1d13c380-9a4d-4c1f-9255-703d3bbf3013Symplectic Elements at OxfordThieme Publishing2015Robertson, GFarley, ADixon, DThe enantioselective phospha-Mannich reaction of diethyl phosphite to unactivated N-DPP-protected ketimines catalyzed by a bifunctional iminophosphorane (BIMP) superbase organocatalyst is described. The reaction is applicable to ketimines bearing electron-rich and electron-poor aryl substituents and occurs with excellent yields and moderate enantioselectivities under mild reaction conditions. |
| spellingShingle | Robertson, G Farley, A Dixon, D Bifunctional iminophosphorane catalyzed enantioselective ketimine phospha-Mannich reaction |
| title | Bifunctional iminophosphorane catalyzed enantioselective ketimine phospha-Mannich reaction |
| title_full | Bifunctional iminophosphorane catalyzed enantioselective ketimine phospha-Mannich reaction |
| title_fullStr | Bifunctional iminophosphorane catalyzed enantioselective ketimine phospha-Mannich reaction |
| title_full_unstemmed | Bifunctional iminophosphorane catalyzed enantioselective ketimine phospha-Mannich reaction |
| title_short | Bifunctional iminophosphorane catalyzed enantioselective ketimine phospha-Mannich reaction |
| title_sort | bifunctional iminophosphorane catalyzed enantioselective ketimine phospha mannich reaction |
| work_keys_str_mv | AT robertsong bifunctionaliminophosphoranecatalyzedenantioselectiveketiminephosphamannichreaction AT farleya bifunctionaliminophosphoranecatalyzedenantioselectiveketiminephosphamannichreaction AT dixond bifunctionaliminophosphoranecatalyzedenantioselectiveketiminephosphamannichreaction |