Exploiting the stress response to radiation to sensitize poorly immunogenic tumors to anti-CTLA-4 treatment.
Radiotherapy sensitizes unresponsive tumors to the antineoplastic activity of antibodies that target the inhibitory receptor CTLA-4 on T cells. One molecular mechanism accounting for this therapeutic synergy is the induction of NKG2D ligands on irradiated tumor cells. The fact that NKG2D receptors m...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2013
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