Spirocyclic tetramates by sequential Knoevenagel and [1,5]-prototropic shift

Highly functionalised spirocyclic tetramates were prepared via tert-amino reaction of bicyclic tetramates. While these compounds isomerise in solution, stable analogues can be prepared via appropriate choice of substituents. Further modification of these compounds allows for introduction of aromatic...

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Main Authors: Josa-Culleré, L, Hirst, MG, Lockett, JP, Thompson, AL, Moloney, MG
Format: Journal article
Language:English
Published: American Chemical Society 2019
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author Josa-Culleré, L
Hirst, MG
Lockett, JP
Thompson, AL
Moloney, MG
author_facet Josa-Culleré, L
Hirst, MG
Lockett, JP
Thompson, AL
Moloney, MG
author_sort Josa-Culleré, L
collection OXFORD
description Highly functionalised spirocyclic tetramates were prepared via tert-amino reaction of bicyclic tetramates. While these compounds isomerise in solution, stable analogues can be prepared via appropriate choice of substituents. Further modification of these compounds allows for introduction of aromatic groups, making them suitable as skeletal suitable for application in medicinal chemistry.
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spelling oxford-uuid:1df10e2e-d326-4c94-91fe-380f5d3a35772022-03-26T11:13:40ZSpirocyclic tetramates by sequential Knoevenagel and [1,5]-prototropic shiftJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:1df10e2e-d326-4c94-91fe-380f5d3a3577EnglishSymplectic Elements at OxfordAmerican Chemical Society2019Josa-Culleré, LHirst, MGLockett, JPThompson, ALMoloney, MGHighly functionalised spirocyclic tetramates were prepared via tert-amino reaction of bicyclic tetramates. While these compounds isomerise in solution, stable analogues can be prepared via appropriate choice of substituents. Further modification of these compounds allows for introduction of aromatic groups, making them suitable as skeletal suitable for application in medicinal chemistry.
spellingShingle Josa-Culleré, L
Hirst, MG
Lockett, JP
Thompson, AL
Moloney, MG
Spirocyclic tetramates by sequential Knoevenagel and [1,5]-prototropic shift
title Spirocyclic tetramates by sequential Knoevenagel and [1,5]-prototropic shift
title_full Spirocyclic tetramates by sequential Knoevenagel and [1,5]-prototropic shift
title_fullStr Spirocyclic tetramates by sequential Knoevenagel and [1,5]-prototropic shift
title_full_unstemmed Spirocyclic tetramates by sequential Knoevenagel and [1,5]-prototropic shift
title_short Spirocyclic tetramates by sequential Knoevenagel and [1,5]-prototropic shift
title_sort spirocyclic tetramates by sequential knoevenagel and 1 5 prototropic shift
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AT thompsonal spirocyclictetramatesbysequentialknoevenageland15prototropicshift
AT moloneymg spirocyclictetramatesbysequentialknoevenageland15prototropicshift