Spirocyclic tetramates by sequential Knoevenagel and [1,5]-prototropic shift
Highly functionalised spirocyclic tetramates were prepared via tert-amino reaction of bicyclic tetramates. While these compounds isomerise in solution, stable analogues can be prepared via appropriate choice of substituents. Further modification of these compounds allows for introduction of aromatic...
Main Authors: | , , , , |
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Format: | Journal article |
Language: | English |
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American Chemical Society
2019
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_version_ | 1797057175173988352 |
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author | Josa-Culleré, L Hirst, MG Lockett, JP Thompson, AL Moloney, MG |
author_facet | Josa-Culleré, L Hirst, MG Lockett, JP Thompson, AL Moloney, MG |
author_sort | Josa-Culleré, L |
collection | OXFORD |
description | Highly functionalised spirocyclic tetramates were prepared via tert-amino reaction of bicyclic tetramates. While these compounds isomerise in solution, stable analogues can be prepared via appropriate choice of substituents. Further modification of these compounds allows for introduction of aromatic groups, making them suitable as skeletal suitable for application in medicinal chemistry. |
first_indexed | 2024-03-06T19:32:31Z |
format | Journal article |
id | oxford-uuid:1df10e2e-d326-4c94-91fe-380f5d3a3577 |
institution | University of Oxford |
language | English |
last_indexed | 2024-03-06T19:32:31Z |
publishDate | 2019 |
publisher | American Chemical Society |
record_format | dspace |
spelling | oxford-uuid:1df10e2e-d326-4c94-91fe-380f5d3a35772022-03-26T11:13:40ZSpirocyclic tetramates by sequential Knoevenagel and [1,5]-prototropic shiftJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:1df10e2e-d326-4c94-91fe-380f5d3a3577EnglishSymplectic Elements at OxfordAmerican Chemical Society2019Josa-Culleré, LHirst, MGLockett, JPThompson, ALMoloney, MGHighly functionalised spirocyclic tetramates were prepared via tert-amino reaction of bicyclic tetramates. While these compounds isomerise in solution, stable analogues can be prepared via appropriate choice of substituents. Further modification of these compounds allows for introduction of aromatic groups, making them suitable as skeletal suitable for application in medicinal chemistry. |
spellingShingle | Josa-Culleré, L Hirst, MG Lockett, JP Thompson, AL Moloney, MG Spirocyclic tetramates by sequential Knoevenagel and [1,5]-prototropic shift |
title | Spirocyclic tetramates by sequential Knoevenagel and [1,5]-prototropic shift |
title_full | Spirocyclic tetramates by sequential Knoevenagel and [1,5]-prototropic shift |
title_fullStr | Spirocyclic tetramates by sequential Knoevenagel and [1,5]-prototropic shift |
title_full_unstemmed | Spirocyclic tetramates by sequential Knoevenagel and [1,5]-prototropic shift |
title_short | Spirocyclic tetramates by sequential Knoevenagel and [1,5]-prototropic shift |
title_sort | spirocyclic tetramates by sequential knoevenagel and 1 5 prototropic shift |
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