CONCISE RACEMIC AND HIGHLY ENANTIOSELECTIVE APPROACHES TO KEY INTERMEDIATES FOR THE SYNTHESES OF CARBOCYCLIC NUCLEOSIDES AND PSEUDO-RIBOFURANOSES - FORMAL SYNTHESES OF CARBOVIR
A regio- and stereo-specific synthesis of cis-(±)-3-acetoxy-5- (acetoxymethyl)cyclopentene 3 from cyclopent-3-enecarboxylic acid 4 via a bromolactonisation strategy is described. Pd-catalysed coupling of the cis-(±)-diacetate 3 with 2-amino-6-chloropurine or 2,6-diaminopurine leads to the formal syn...
| Glavni autori: | , , |
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| Format: | Journal article |
| Jezik: | English |
| Izdano: |
1994
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