Human genetics uncovers MAP3K15 as an obesity-independent therapeutic target for diabetes

Human genetics uncovers MAP3K15 as an obesity-independent therapeutic target for diabetes

<p>We performed collapsing analyses on 454,796 UK Biobank (UKB) exomes to detect gene-level associations with diabetes. Recessive carriers of nonsynonymous variants in&nbsp;<em>MAP3K15</em>&nbsp;were 30% less likely to develop diabetes (<em>P</em>&nbsp;= 5.7...

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Main Authors: Nag, A, Dhindsa, RS, Mitchell, J, Vasavda, C, Harper, AR, Vitsios, D, Ahnmark, A, Bilican, B, Madeyski-Bengtson, K, Zarrouki, B, Zoghbi, AW, Wang, Q, Smith, KR, Alegre-Díaz, J, Kuri-Morales, P, Berumen, J, Tapia-Conyer, R, Emberson, J, Torres, JM, Collins, R, Smith, DM, Challis, B, Paul, DS, Bohlooly-Y, M, Snowden, M, Baker, D, Fritsche-Danielson, R, Pangalos, MN, Petrovski, S
Format: Journal article
Language:English
Published: American Association for the Advancement of Science 2022

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