Hypoxia promotes the production and inhibits the destruction of human articular cartilage.

OBJECTIVE: To determine the effects of hypoxia on both anabolic and catabolic pathways of metabolism in human articular cartilage and to elucidate the roles played by hypoxia-inducible factors (HIFs) in these responses. METHODS: Normal human articular cartilage from a range of donors was obtained a...

Full description

Bibliographic Details
Main Authors: Thoms, B, Dudek, K, Lafont, J, Murphy, C
Format: Journal article
Language:English
Published: 2013