Hypoxia promotes the production and inhibits the destruction of human articular cartilage.
OBJECTIVE: To determine the effects of hypoxia on both anabolic and catabolic pathways of metabolism in human articular cartilage and to elucidate the roles played by hypoxia-inducible factors (HIFs) in these responses. METHODS: Normal human articular cartilage from a range of donors was obtained a...
Main Authors: | Thoms, B, Dudek, K, Lafont, J, Murphy, C |
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Format: | Journal article |
Language: | English |
Published: |
2013
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