Discovery of HLA-E-presented epitopes: MHC-E/Peptide binding and t-cell recognition

Understanding the interactions involved during the immunological synapse between peptide, HLA-E molecules, and TCR is crucial to effectively target protective HLA-E-restricted T-cell responses in humans. Here we describe three techniques based on the generation of MHC-E/peptide complexes (MHC-E gene...

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Bibliographic Details
Main Authors: Ruibal, P, Franken, KLMC, van Meijgaarden, KE, Walters, LC, McMichael, AJ, Gillespie, GM, Joosten, SA, Ottenhoff, THM
Format: Journal article
Language:English
Published: Springer 2022