An individual participant data population pharmacokinetic meta-analysis of drug-drug interactions between lumefantrine and commonly used antiretroviral treatment

Treating malaria in HIV-coinfected individuals should consider potential drug-drug interactions. Artemether-lumefantrine is the most widely recommended treatment for uncomplicated malaria globally. Lumefantrine is metabolized by CYP3A4, an enzyme that commonly used antiretrovirals often induce or in...

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Main Authors: Francis, J, Barnes, KI, Workman, L, Kredo, T, Vestergaard, LS, Hoglund, RM, Byakika-Kibwika, P, Lamorde, M, Walimbwa, SI, Chijioke-Nwauche, I, Sutherland, CJ, Merry, C, Scarsi, KK, Nyagonde, N, Lemnge, MM, Khoo, SH, Bygbjerg, IC, Parikh, S, Aweeka, FT, Tarning, J, Denti, P
Format: Journal article
Language:English
Published: American Society for Microbiology 2020