Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing.
This article outlines the need for a homeostatic response to alterations in cellular oxygenation. It describes work on erythropoietin control that led to the discovery of the hypoxia-inducible transcription factor (HIF-1) and the parallel recognition that this system was responsive to a widespread o...
| Үндсэн зохиолчид: | , , |
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| Формат: | Journal article |
| Хэл сонгох: | English |
| Хэвлэсэн: |
2009
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| _version_ | 1826262448087236608 |
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| author | Webb, J Coleman, M Pugh, C |
| author_facet | Webb, J Coleman, M Pugh, C |
| author_sort | Webb, J |
| collection | OXFORD |
| description | This article outlines the need for a homeostatic response to alterations in cellular oxygenation. It describes work on erythropoietin control that led to the discovery of the hypoxia-inducible transcription factor (HIF-1) and the parallel recognition that this system was responsive to a widespread oxygen-sensing mechanism. Subsequently, multiple HIF isoforms have been shown to have overlapping but non-redundant functions, controlling expression of genes involved in diverse processes such as angiogenesis, vascular tone, metal transport, glycolysis, mitochondrial function, cell growth and survival. The major role of prolyl and asparaginyl hydroxylation in regulating HIFs is described, as well as the identification of PHD1-3 and FIH as the oxygen-sensing enzymes responsible for these hydroxylations. Current understanding of other processes that modulate overall HIF activity, including influences from other signalling mechanisms such as kinases and nitric oxide levels, and the existence of a variety of feedback loops are outlined. The effects of some mutations in this pathway are documented as is knowledge of other substrates for these enzymes. The importance of PHD1-3 and FIH, and the large family of 2-oxoglutarate and iron(II)-dependent dioxygenases of which they are a part, in biology and medicine are discussed. |
| first_indexed | 2024-03-06T19:36:19Z |
| format | Journal article |
| id | oxford-uuid:1f2c5ba0-58a1-4ef1-af38-d4b2f6cb2dcd |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:36:19Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:1f2c5ba0-58a1-4ef1-af38-d4b2f6cb2dcd2022-03-26T11:20:25ZHypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:1f2c5ba0-58a1-4ef1-af38-d4b2f6cb2dcdEnglishSymplectic Elements at Oxford2009Webb, JColeman, MPugh, CThis article outlines the need for a homeostatic response to alterations in cellular oxygenation. It describes work on erythropoietin control that led to the discovery of the hypoxia-inducible transcription factor (HIF-1) and the parallel recognition that this system was responsive to a widespread oxygen-sensing mechanism. Subsequently, multiple HIF isoforms have been shown to have overlapping but non-redundant functions, controlling expression of genes involved in diverse processes such as angiogenesis, vascular tone, metal transport, glycolysis, mitochondrial function, cell growth and survival. The major role of prolyl and asparaginyl hydroxylation in regulating HIFs is described, as well as the identification of PHD1-3 and FIH as the oxygen-sensing enzymes responsible for these hydroxylations. Current understanding of other processes that modulate overall HIF activity, including influences from other signalling mechanisms such as kinases and nitric oxide levels, and the existence of a variety of feedback loops are outlined. The effects of some mutations in this pathway are documented as is knowledge of other substrates for these enzymes. The importance of PHD1-3 and FIH, and the large family of 2-oxoglutarate and iron(II)-dependent dioxygenases of which they are a part, in biology and medicine are discussed. |
| spellingShingle | Webb, J Coleman, M Pugh, C Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing. |
| title | Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing. |
| title_full | Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing. |
| title_fullStr | Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing. |
| title_full_unstemmed | Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing. |
| title_short | Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing. |
| title_sort | hypoxia hypoxia inducible factors hif hif hydroxylases and oxygen sensing |
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