Discovery of orally bioavailable, quinoline-based aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with potent cellular activity

Aldehyde dehydrogenases (ALDHs) are responsible for the metabolism of aldehydes (exogenous and endogenous) and possess vital physiological and toxicological functions in areas such as CNS, inflammation, metabolic disorders, and cancers. Overexpression of certain ALDHs (e.g. ALDH1A1) are important bi...

Full description

Bibliographic Details
Main Authors:	Yang, S, Martinez, N, Yasgar, A, Danchik, C, Johansson, C, Wang, Y, Baljinnyam, B, Wang, A, Xu, X, Shah, P, Cheff, D, Wang, X, Roth, J, Lal-Nag, M, Dunford, J, Oppermann, U, Vasiliou, V, Simeonov, A, Jadhav, A, Maloney, D
Format:	Journal article
Published:	American Chemical Society 2018

Discovery of orally bioavailable, quinoline-based aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with potent cellular activity

Similar Items