Mutational analysis of Portuguese families with multiple endocrine neoplasia type 1 reveals large germline deletions.

Mutational analysis of Portuguese families with multiple endocrine neoplasia type 1 reveals large germline deletions.

OBJECTIVE: To determine the spectrum of MEN1 mutations in Portuguese kindreds, and identify mutation-carriers. PATIENTS, DESIGN AND RESULTS: Six unrelated MEN1 families were studied for MEN1 gene mutations by single-strand conformational polymorphism (SSCP) and DNA sequence analysis of the coding r...

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Bibliographic Details
Main Authors: Cavaco, B, Domingues, R, Bacelar, M, Cardoso, H, Barros, L, Gomes, L, Ruas, M, Agapito, A, Garrão, A, Pannett, A, Silva, J, Sobrinho, L, Thakker, R, Leite, V
Format: Journal article
Language:English
Published: 2002

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