2 '-Substituted 2-amino-3-methylpyridine ribonucleosides in triplex-forming oligonucleotides: triplex stability is determined by chemical environment
A new synthetic route to the phosphoramidite monomer of 2-amino-3-methyl-5-(2′-O-methyl-β-d-ribofuranosyl)pyridine (Me-MAP) and its 2′-O-methoxyethyl analogue (MOE-MAP) has been established using d-ribose and 2-amino-3-methyl-5-bromopyridine as precursors. Ultraviolet melting and DNase I footprintin...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2011
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