Expression, purification, cocrystallization and preliminary crystallographic analysis of sucrose octasulfate/human complement regulator factor H SCRs 6-8.

Expression, purification, cocrystallization and preliminary crystallographic analysis of sucrose octasulfate/human complement regulator factor H SCRs 6-8.

Human plasma protein complement factor H (FH) is an inhibitor of the spontaneously activated alternative complement pathway. An allotypic variant of FH, 402His, has been associated with age-related macular degeneration, the leading cause of blindness in the elderly. Crystals of FH domains 6-8 (FH678...

Полное описание

Библиографические подробности
Главные авторы:	Prosser, B, Johnson, S, Roversi, P, Clark, S, Tarelli, E, Sim, R, Day, A, Lea, S
Формат:	Journal article
Язык:	English
Опубликовано:	2007

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