Studies on the selectivity of the SARS-CoV-2 papain-like protease reveal the importance of the P2' proline of the viral polyprotein

The SARS-CoV-2 papain-like protease (PLpro) is an antiviral drug target that catalyzes the hydrolysis of the viral polyproteins pp1a/1ab, so releasing the non-structural proteins (nsps) 1–3 that are essential for the coronavirus lifecycle. The LXGG↓X motif in pp1a/1ab is crucial for recognition and...

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書目詳細資料
Main Authors: Chan, HTH, Brewitz, L, Lukacik, P, Strain-Damerell, C, Walsh, MA, Schofield, CJ, Duarte, F
格式: Journal article
語言:English
出版: Royal Society of Chemistry 2023