Fine tuning gene expression levels in mammalian cells with engineered microRNA target sites

<p>Precise, analogue regulation of gene expression is critical for development, homeostasis and regeneration in mammals. In contrast, widely employed experimental and therapeutic approaches such as knock-in/out strategies are more suitable for binary control of gene activity, while RNA interfe...

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Bibliographic Details
Main Author: Michaels, Y
Other Authors: Fulga, T
Format: Thesis
Published: 2018
Subjects: