Sequence-dependent bending of DNA induced by cisplatin: NMR structures of an A.T-rich 14-mer duplex.

The NMR solution structure of the A.T rich DNA 14-mer duplex d(ATACATGGTACATA).d(TATGTACCATGTAT) is reported. This is compared with the NMR structure of the same duplex intrastrand cross-linked at the d(G*pG*) site by cis-(Pt(NH3)2¿2+, derived from the anticancer drug cisplatin. The unmodified duple...

詳細記述

書誌詳細
主要な著者: Parkinson, J, Chen, Y, del Socorro Murdoch, P, Guo, Z, Berners-Price, S, Brown, T, Sadler, P
フォーマット: Journal article
言語:English
出版事項: 2000