Sequence-dependent bending of DNA induced by cisplatin: NMR structures of an A.T-rich 14-mer duplex.

Sequence-dependent bending of DNA induced by cisplatin: NMR structures of an A.T-rich 14-mer duplex.

The NMR solution structure of the A.T rich DNA 14-mer duplex d(ATACATGGTACATA).d(TATGTACCATGTAT) is reported. This is compared with the NMR structure of the same duplex intrastrand cross-linked at the d(G*pG*) site by cis-(Pt(NH3)2¿2+, derived from the anticancer drug cisplatin. The unmodified duple...

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Xehetasun bibliografikoak
Egile Nagusiak:	Parkinson, J, Chen, Y, del Socorro Murdoch, P, Guo, Z, Berners-Price, S, Brown, T, Sadler, P
Formatua:	Journal article
Hizkuntza:	English
Argitaratua:	2000

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