Catechol-O-methyltransferase inhibition improves set-shifting performance and elevates stimulated dopamine release in the rat prefrontal cortex
The Val 158 Met polymorphism of the human catechol-O-methyltransferase (COMT) gene affects activity of the enzyme and influences performance and efficiency of the prefrontal cortex (PFC); however, although catecholaminergic neurotransmission is implicatedm the underlying mechanisms remain elusive be...
Autores principales: | , , , |
---|---|
Formato: | Journal article |
Lenguaje: | English |
Publicado: |
Society for Neuroscience
2004
|
Materias: |