Catechol-O-methyltransferase inhibition improves set-shifting performance and elevates stimulated dopamine release in the rat prefrontal cortex

The Val 158 Met polymorphism of the human catechol-O-methyltransferase (COMT) gene affects activity of the enzyme and influences performance and efficiency of the prefrontal cortex (PFC); however, although catecholaminergic neurotransmission is implicatedm the underlying mechanisms remain elusive be...

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Detalles Bibliográficos
Autores principales: Tunbridge, E, Bannerman, D, Sharp, T, Harrison, P
Formato: Journal article
Lenguaje:English
Publicado: Society for Neuroscience 2004
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