Immunization against GAD induces antibody binding to GAD-independent antigens and brainstem GABAergic neuronal loss
Stiff person syndrome (SPS) is a highly-disabling neurological disorder of the CNS characterized by progressive muscular rigidity and spasms. In approximately 60–80% of patients there are autoantibodies to glutamic acid decarboxylase (GAD), the enzyme that synthesizes gamma-amino butyric acid (GABA)...
Main Authors: | Chang, T, Alexopoulos, H, Pettingill, P, McMenamin, M, Deacon, R, Erdelyi, F, Szabó, G, Buckley, C, Vincent, A |
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Format: | Journal article |
Language: | English |
Published: |
Public Library of Science
2013
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