Crystallographic studies of shikimate binding and induced conformational changes in Mycobacterium tuberculosis shikimate kinase.

The X-ray crystal structure of Mycobacterium tuberculosis shikimate kinase (SK) with bound shikimate and adenosine diphosphate (ADP) has been determined to a resolution of 2.15 A. The binding of shikimate in a shikimate kinase crystal structure has not previously been reported. The substrate binds i...

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Detalhes bibliográficos
Principais autores: Dhaliwal, B, Nichols, C, Ren, J, Lockyer, M, Charles, I, Hawkins, A, Stammers, D
Formato: Journal article
Idioma:English
Publicado em: 2004