Calmodulin dissociation mediates desensitization of the cADPR-induced Ca2+ release mechanism.

Calmodulin dissociation mediates desensitization of the cADPR-induced Ca2+ release mechanism.

Ryanodine receptor (RyR) activation by cyclic ADP-ribose (cADPR) is followed by homologous desensitization. Though poorly understood, this "switching off" process has provided a key experimental tool for determining the pathway through which cADPR mediates Ca(2+) release. Moreover, desensi...

Podrobná bibliografie
Hlavní autoři:	Thomas, J, Summerhill, R, Fruen, B, Churchill, G, Galione, A
Médium:	Journal article
Jazyk:	English
Vydáno:	2002

Podobné jednotky

Requirement of calmodulin for actions of cADPR in guinea-pig ventricular myocytes
Autor: Rakovic, S, a další
Vydáno: (2002)

Carvedilol inhibits cADPR- and IP3-induced Ca2+ release
Autor: Morgan, A, a další
Vydáno: (2017)

NAADP and cADPR signalling in sea urchin eggs
Autor: Galione, A, a další
Vydáno: (2005)

Pharmacological characteristics of [P-32] cADPR binding to sea urchin egg homogenate
Autor: Thomas, J, a další
Vydáno: (2000)

Investigating cADPR and NAADP in intact and broken cell preparations.
Autor: Morgan, A, a další
Vydáno: (2008)

NAADP induces Ca2+ oscillations via a two-pool mechanism by priming IP3- and cADPR-sensitive Ca2+ stores.
Autor: Churchill, G, a další
Vydáno: (2001)

The functional roles of Ca2+ mobilizing pyridine nucleotides cADPR and NAADP in detrusor and taenia caceum
Autor: Durlu-Kandilci, N, a další
Vydáno: (2007)

Role of NAADP and cADPR in the induction and maintenance of agonist-evoked Ca2+ spiking in mouse pancreatic acinar cells.
Autor: Yamasaki, M, a další
Vydáno: (2005)

β-Adrenergic receptor signaling increases NAADP and cADPR levels in the heart.
Autor: Lewis, A, a další
Vydáno: (2012)

ß-Adrenergic receptor signaling increases NAADP and cADPR levels in the heart
Autor: Lewis, A, a další
Vydáno: (2012)

A pivotal role for cADPR-mediated Ca2+ signaling: regulation of endothelin-induced contraction in peritubular smooth muscle cells.
Autor: Barone, F, a další
Vydáno: (2002)

cADPR stimulates SERCA activity in Xenopus oocytes.
Autor: Yamasaki-Mann, M, a další
Vydáno: (2009)

Concise Syntheses of Trifluoromethylated Cyclic and Acyclic Analogues of cADPR
Autor: Lihe Zhang, a další
Vydáno: (2010-11-01)

Direct Gating of the TRPM2 Channel by cADPR via Specific Interactions with the ADPR Binding Pocket
Autor: Peilin Yu, a další
Vydáno: (2019-06-01)

Interactions between intracellular Ca2+ stores: Ca2+ released from the NAADP pool potentiates cADPR-induced Ca2+ release
Autor: E.N. Chini
Vydáno: (2002-05-01)

CD38/cADPR Signaling Pathway in Airway Disease: Regulatory Mechanisms
Autor: Deepak A. Deshpande, a další
Vydáno: (2018-01-01)

Synthetic cADPR analogues may form only one of two possible conformational diastereoisomers
Autor: Watt, J, a další
Vydáno: (2018)

Synthesis of the Ca2+-mobilizing messengers NAADP and cADPR by intracellular CD38 enzyme in the mouse heart: Role in β-adrenoceptor signaling
Autor: Lin, W, a další
Vydáno: (2017)

Does Cyclic ADP-Ribose (cADPR) Activate the Non-selective Cation Channel TRPM2?
Autor: Ralf Fliegert, a další
Vydáno: (2020-08-01)

2'-deoxy cyclic adenosine 5'-diphosphate ribose derivatives: importance of the 2'-hydroxyl motif for the antagonistic activity of 8-substituted cADPR derivatives.
Autor: Zhang, B, a další
Vydáno: (2008)

Arginine Thiazolidine Carboxylate Stimulates Insulin Secretion through Production of Ca2+-Mobilizing Second Messengers NAADP and cADPR in Pancreatic Islets.
Autor: Dae-Ryoung Park, a další
Vydáno: (2015-01-01)

Synthesis and Calcium Mobilization Activity of cADPR Analogues Which Integrate Nucleobase, Northern and Southern Ribose Modifications
Autor: Liangren Zhang, a další
Vydáno: (2012-04-01)

Synthesis of cyclic adenosine 5'-diphosphate ribose analogues: a C2'endo/syn "southern" ribose conformation underlies activity at the sea urchin cADPR receptor.
Autor: Moreau, C, a další
Vydáno: (2011)

Remifentanil-induced postoperative hyperalgesia is attenuated by inhibition of NMDAR-cADPR-RyRs signaling pathway in the spinal cord of rats
Autor: QIAN Yue, WANG Fang, ZHANG Jing, XIA Tianjiao, GU Xiaoping
Vydáno: (2023-09-01)

CD38-cADPR-SERCA Signaling Axis Determines Skeletal Muscle Contractile Force in Response to β-Adrenergic Stimulation
Autor: Dae-Ryoung Park, a další
Vydáno: (2018-04-01)

New Linear Precursors of cIDPR Derivatives as Stable Analogs of cADPR: A Potent Second Messenger with Ca<sup>2+</sup>-Modulating Activity Isolated from Sea Urchin Eggs
Autor: Stefano D’Errico, a další
Vydáno: (2019-08-01)

Synthesis of cyclic N1-pentylinosine phosphate, a new structurally reduced cADPR analogue with calcium-mobilizing activity on PC12 cells
Autor: Ahmed Mahal, a další
Vydáno: (2015-12-01)

Synthesis and Biological Evaluation of a New Structural Simplified Analogue of cADPR, a Calcium-Mobilizing Secondary Messenger Firstly Isolated from Sea Urchin Eggs
Autor: Stefano D’Errico, a další
Vydáno: (2018-03-01)

Prolonged inactivation of nicotinic acid adenine dinucleotide phosphate-induced Ca2+ release mediates a spatiotemporal Ca2+ memory.
Autor: Churchill, G, a další
Vydáno: (2001)

2′-deoxy-ADPR activates human TRPM2 faster than ADPR and thereby induces higher currents at physiological Ca2+ concentrations
Autor: Jelena Pick, a další
Vydáno: (2024-01-01)

Cerebellar Kainate Receptor-Mediated Facilitation of Glutamate Release Requires Ca2+-Calmodulin and PKA
Autor: Rafael Falcón-Moya, a další
Vydáno: (2018-06-01)

Distinct pharmacology of 2-hydroxycarbazole-induced Ca2+ release in the sea urchin egg.
Autor: Thomas, J, a další
Vydáno: (2001)

Cell-permeant small-molecule modulators of NAADP-mediated Ca2+ release.
Autor: Dowden, J, a další
Vydáno: (2006)

Ca2+/Calmodulin and Apo-Calmodulin Both Bind to and Enhance the Tyrosine Kinase Activity of c-Src.
Autor: Silviya R Stateva, a další
Vydáno: (2015-01-01)

Does NAADP-induced Ca2+ release contribute to glucose-induced (ca(2+))(i) changes in primary mouse pancreatic beta-cell?
Autor: Arredouani, A, a další
Vydáno: (2006)

Calcium and calmodulin mediation of growth hormone-releasing hormone release from the rat hypothalamus in vitro.
Autor: Honegger, J, a další
Vydáno: (1991)

Role of protein kinase C and calmodulin in histamine release in experimental filariasis
Autor: Muralidhara P, a další
Vydáno: (1998-01-01)

Calmodulin dissociates the STIM1-Orai1 complex and STIM1 oligomers
Autor: Xin Li, a další
Vydáno: (2017-10-01)

Inhibition of TRPP3 by calmodulin through Ca2+/calmodulin-dependent protein kinase II
Autor: Xiong Liu, a další
Vydáno: (2023-04-01)

A dynamic model of interactions of Ca2+, calmodulin, and catalytic subunits of Ca2+/calmodulin-dependent protein kinase II.
Autor: Shirley Pepke, a další
Vydáno: (2010-02-01)