Structure and inhibitor specificity of the PCTAIRE-family kinase CDK16.
CDK16 (also known as PCTAIRE1 or PCTK1) is an atypical member of the cyclin-dependent kinase (CDK) family that has emerged as a key regulator of neurite outgrowth, vesicle trafficking and cancer cell proliferation. CDK16 is activated through binding to cyclin Y via a phosphorylation-d...
Main Authors: | Dixon-Clarke, S, Shehata, S, Krojer, T, Sharpe, T, von Delft, F, Sakamoto, K, Bullock, A |
---|---|
Format: | Journal article |
Language: | English |
Published: |
Portland Press
2017
|
Similar Items
-
Insights into the structural and functional activities of forgotten Kinases: PCTAIREs CDKs
by: Javad Karimbayli, et al.
Published: (2024-06-01) -
Lipid Nanoparticle-mediated siRNA Transfer Against PCTAIRE1/PCTK1/Cdk16 Inhibits In Vivo Cancer Growth
by: Teruki Yanagi, et al.
Published: (2016-01-01) -
PCTAIRE1-knockdown sensitizes cancer cells to TNF family cytokines.
by: Teruki Yanagi, et al.
Published: (2015-01-01) -
The regulation of tau phosphorylation by PCTAIRE 3: Implications for the pathogenesis of Alzheimer's disease
by: A.Z. Herskovits, et al.
Published: (2006-08-01) -
Cyclin-dependent kinase 12 (CDK12), human kinase domain; a Target Enabling Package
by: Dixon-Clarke, S
Published: (2018)