Reduced levels of neuraminidase of influenza A viruses correlate with attenuated phenotypes in mice.

We have previously obtained four transfectant influenza A viruses containing neuraminidase (NA) genes with mutated base pairs in the conserved double-stranded RNA region of the viral promoter by using a ribonucleoprotein transfection system. Two mutant viruses (D2 and D1/2) which share a C-G--&g...

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Bibliographic Details
Main Authors: Solorzano, A, Zheng, H, Fodor, E, Brownlee, G, Palese, P, García-Sastre, A
Format: Journal article
Language:English
Published: 2000