Kinetic analysis of novel multisubstrate analogue inhibitors of thymidine phosphorylase.

A kinetic analysis was performed for the novel 1-(8-phosphonooctyl)-6-amino-5-bromouracil and 1-(8-phosphonooctyl)-7-deazaxanthine inhibitors of Escherichia coli thymidine (dThd) phosphorylase (TPase). The structure of the compounds was rationally designed based on the available crystal structure co...

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Những tác giả chính: Balzarini, J, Degrève, B, Esteban-Gamboa, A, Esnouf, R, De Clercq, E, Engelborghs, Y, Camarasa, M, Pérez-Pérez, M
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: 2000