Kinetic analysis of novel multisubstrate analogue inhibitors of thymidine phosphorylase.

A kinetic analysis was performed for the novel 1-(8-phosphonooctyl)-6-amino-5-bromouracil and 1-(8-phosphonooctyl)-7-deazaxanthine inhibitors of Escherichia coli thymidine (dThd) phosphorylase (TPase). The structure of the compounds was rationally designed based on the available crystal structure co...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron: Balzarini, J, Degrève, B, Esteban-Gamboa, A, Esnouf, R, De Clercq, E, Engelborghs, Y, Camarasa, M, Pérez-Pérez, M
Fformat: Journal article
Iaith:English
Cyhoeddwyd: 2000