Characterization of human DHRS6, an orphan short chain dehydrogenase/reductase enzyme: a novel, cytosolic type 2 R-beta-hydroxybutyrate dehydrogenase

Characterization of human DHRS6, an orphan short chain dehydrogenase/reductase enzyme: a novel, cytosolic type 2 R-beta-hydroxybutyrate dehydrogenase

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Human DHRS6 is a previously uncharacterized member of the short chain dehydrogenases/reductase family and displays significant homologies to bacterial hydroxybutyrate dehydrogenases. Substrate screening reveals sole NAD(+)-dependent conversion of (R)-hydroxybutyrate to acetoacetate with K(m) values...

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Bibliographic Details
Main Authors: Guo, K, Lukacik, P, Papagrigoriou, E, Meier, M, Lee, W, Adamski, J, Oppermann, U
Format: Journal article
Language:English
Published: American Society for Biochemistry and Molecular Biology 2006
Subjects:
Oxidoreductases
Arginine
Dose-Response Relationship, Drug
Exons
genetics
Lipids
enzymology
Hydrogen-Ion Concentration
Green Fluorescent Proteins
Hela Cells
Hydroxybutyrate Dehydrogenase
Crystallography, X-Ray
Protein Structure, Tertiary
Cloning, Molecular
Amino Acid Motifs
Cytosol
metabolism
Kinetics
Sulfates
Sequence Homology, Amino Acid
Protein Conformation
Amino Acid Sequence
Phylogeny
Molecular Sequence Data
Mitochondria
Binding Sites
Protein Folding
Models, Molecular
chemistry
Substrate Specificity

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