Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes.
Highly active antiretroviral therapy (HAART) has been advocated for the management of primary HIV-1 infection without clear understanding of its immunological effects. Here, we demonstrate that early use of HAART during primary infection preserves HIV-specific CD8(+) T cells physically and functiona...
| Prif Awduron: | , , , , , , , , |
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| Fformat: | Journal article |
| Iaith: | English |
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2000
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| _version_ | 1826263168796590080 |
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| author | Oxenius, A Price, D Easterbrook, P O'Callaghan, C Kelleher, A Whelan, J Sontag, G Sewell, A Phillips, R |
| author_facet | Oxenius, A Price, D Easterbrook, P O'Callaghan, C Kelleher, A Whelan, J Sontag, G Sewell, A Phillips, R |
| author_sort | Oxenius, A |
| collection | OXFORD |
| description | Highly active antiretroviral therapy (HAART) has been advocated for the management of primary HIV-1 infection without clear understanding of its immunological effects. Here, we demonstrate that early use of HAART during primary infection preserves HIV-specific CD8(+) T cells physically and functionally while HIV-specific T cell help is sustained. We also show that even transient administration of HAART at seroconversion can preserve HIV-specific immunity. In contrast, delayed initiation of HAART is associated with a progressive loss of HIV-specific CD8(+) T cells and absent HIV-specific T cell help. These results imply that HIV-specific T help is damaged during primary HIV-1 infection. Early drug treatment, which preserves this immunity, also preserves HIV-specific CD8(+) T cells. These results have implications for understanding the early pathogenesis of HIV-1 infection and suggest that acute HIV infection should be treated aggressively and as early as possible. |
| first_indexed | 2024-03-06T19:47:26Z |
| format | Journal article |
| id | oxford-uuid:22cb8661-bece-482c-bb97-85696d9f807e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:47:26Z |
| publishDate | 2000 |
| record_format | dspace |
| spelling | oxford-uuid:22cb8661-bece-482c-bb97-85696d9f807e2022-03-26T11:40:41ZEarly highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:22cb8661-bece-482c-bb97-85696d9f807eEnglishSymplectic Elements at Oxford2000Oxenius, APrice, DEasterbrook, PO'Callaghan, CKelleher, AWhelan, JSontag, GSewell, APhillips, RHighly active antiretroviral therapy (HAART) has been advocated for the management of primary HIV-1 infection without clear understanding of its immunological effects. Here, we demonstrate that early use of HAART during primary infection preserves HIV-specific CD8(+) T cells physically and functionally while HIV-specific T cell help is sustained. We also show that even transient administration of HAART at seroconversion can preserve HIV-specific immunity. In contrast, delayed initiation of HAART is associated with a progressive loss of HIV-specific CD8(+) T cells and absent HIV-specific T cell help. These results imply that HIV-specific T help is damaged during primary HIV-1 infection. Early drug treatment, which preserves this immunity, also preserves HIV-specific CD8(+) T cells. These results have implications for understanding the early pathogenesis of HIV-1 infection and suggest that acute HIV infection should be treated aggressively and as early as possible. |
| spellingShingle | Oxenius, A Price, D Easterbrook, P O'Callaghan, C Kelleher, A Whelan, J Sontag, G Sewell, A Phillips, R Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes. |
| title | Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes. |
| title_full | Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes. |
| title_fullStr | Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes. |
| title_full_unstemmed | Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes. |
| title_short | Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes. |
| title_sort | early highly active antiretroviral therapy for acute hiv 1 infection preserves immune function of cd8 and cd4 t lymphocytes |
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