Increased GTP-cyclohydrolase I expression but not vitamin C treatment restored accelerated atherosclerotic lesion formation in apolipoprotein E-deficient mice overexpressing endothelial nitric oxide synthase

Geahča maid

• GTPCH I overexpression decreases atherosclerotic lesion formation in apolipoprotein E-deficient/eNOS transgenic mice
  Dahkki: Takaya, T, et al.
  Almmustuhtton: (2004)
• Endothelial-targeted GTP cyclohydrolase I overexpression increases endothelial tetrahydrobiopterin levels and preserves eNOS coupling in eNOS overexpressing mice
  Dahkki: Bendall, J, et al.
  Almmustuhtton: (2004)
• Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression.
  Dahkki: Alp, N, et al.
  Almmustuhtton: (2003)
• Endothelial-specific GTP cyclohydrolase overexpression reduces blood pressure in salt-sensitive hypertension
  Dahkki: Chen, A, et al.
  Almmustuhtton: (2006)
• Stoichiometric relationships between endothelial tetrahydrobiopterin, endothelial NO synthase (eNOS) activity, and eNOS coupling in vivo: insights from transgenic mice with endothelial-targeted GTP cyclohydrolase 1 and eNOS overexpression.
  Dahkki: Bendall, J, et al.
  Almmustuhtton: (2005)