Structural and mechanistic studies of the orf12 gene product from the clavulanic acid biosynthesis pathway.
Structural and biochemical studies of the orf12 gene product (ORF12) from the clavulanic acid (CA) biosynthesis gene cluster are described. Sequence and crystallographic analyses reveal two domains: a C-terminal penicillin-binding protein (PBP)/β-lactamase-type fold with highest structural similarit...
المؤلفون الرئيسيون: | Valegård, K, Iqbal, A, Kershaw, N, Ivison, D, Généreux, C, Dubus, A, Blikstad, C, Demetriades, M, Hopkinson, R, Lloyd, A, Roper, D, Schofield, C, Andersson, I, McDonough, M |
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التنسيق: | Journal article |
اللغة: | English |
منشور في: |
2013
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مواد مشابهة
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Clavulanic acid dehydrogenase: structural and biochemical analysis of the final step in the biosynthesis of the beta-lactamase inhibitor clavulanic acid.
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Chemistry and biosynthesis of clavulanic acid and other clavams.
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