Oxygen sensing by HIF hydroxylases.
The transcription factor HIF (hypoxia-inducible factor) has a central role in oxygen homeostasis in animals ranging from nematode worms to man. Recent studies have shown that this factor is regulated by an unprecedented signalling mechanism that involves post-translational hydroxylation. This hydrox...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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2004
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| _version_ | 1826263251712737280 |
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| author | Schofield, C Ratcliffe, P |
| author_facet | Schofield, C Ratcliffe, P |
| author_sort | Schofield, C |
| collection | OXFORD |
| description | The transcription factor HIF (hypoxia-inducible factor) has a central role in oxygen homeostasis in animals ranging from nematode worms to man. Recent studies have shown that this factor is regulated by an unprecedented signalling mechanism that involves post-translational hydroxylation. This hydroxylation is catalysed by a set of non-haem, Fe2+-dependent enzymes that belong to the 2-oxoglutarate-dependent-oxygenase superfamily. The absolute requirement of these enzymes for molecular oxygen has provided new insights into the way cells sense oxygen. |
| first_indexed | 2024-03-06T19:48:46Z |
| format | Journal article |
| id | oxford-uuid:23401cd4-3015-43b8-966c-fe734ec82644 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:48:46Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:23401cd4-3015-43b8-966c-fe734ec826442022-03-26T11:43:19ZOxygen sensing by HIF hydroxylases.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:23401cd4-3015-43b8-966c-fe734ec82644EnglishSymplectic Elements at Oxford2004Schofield, CRatcliffe, PThe transcription factor HIF (hypoxia-inducible factor) has a central role in oxygen homeostasis in animals ranging from nematode worms to man. Recent studies have shown that this factor is regulated by an unprecedented signalling mechanism that involves post-translational hydroxylation. This hydroxylation is catalysed by a set of non-haem, Fe2+-dependent enzymes that belong to the 2-oxoglutarate-dependent-oxygenase superfamily. The absolute requirement of these enzymes for molecular oxygen has provided new insights into the way cells sense oxygen. |
| spellingShingle | Schofield, C Ratcliffe, P Oxygen sensing by HIF hydroxylases. |
| title | Oxygen sensing by HIF hydroxylases. |
| title_full | Oxygen sensing by HIF hydroxylases. |
| title_fullStr | Oxygen sensing by HIF hydroxylases. |
| title_full_unstemmed | Oxygen sensing by HIF hydroxylases. |
| title_short | Oxygen sensing by HIF hydroxylases. |
| title_sort | oxygen sensing by hif hydroxylases |
| work_keys_str_mv | AT schofieldc oxygensensingbyhifhydroxylases AT ratcliffep oxygensensingbyhifhydroxylases |