CD8 helps TCR catch slippery self pMHC

A new model proposes that an applied force allows the co-receptor CD8 and the kinase Lck to selectively stabilize TCR interactions with negatively selecting ligands, but not those with positively selecting ligands, during the negative selection of self-reactive thymocytes.

Xehetasun bibliografikoak
Egile Nagusiak: Dushek, O, Dustin, M
Formatua: Journal article
Argitaratua: Springer Nature 2018